Mukdahan Province is located on the bank of the Mae Khong River opposite Suwannakhet in Laos, 642 kilometers from Bangkok. It is a quiet province bordering the mighty Mekong River. Home to an interesting mixture of cultures from various tribes since ancient times, this rural area of the northeast is a land of fantastic natural rock formations, beautiful sceneries and has an interesting mix of cultures and traditions. Mukdahan is well known for producing good quality Mudmee silk and pillows and sweet tamarind fruit. The town also hosts the Indochine Market, a bustling weekend market selling a whole range of items from Thailand, Laos and Vietnam.

          Wat Si Mongkhon Tai located on the bank of the Mekong River is the temple where Mukdahan's ancient and most revered image of Buddha, the Phra Chao Ong Luang, is enshrined. Amphur Wan Yai is home to Wat Ban Song Khon Church, one of the largest and most beautiful Catholic churches in Asia. Luang Pho Yai a Buddha image sitting in the gesture of giving the First Sermon, is placed on a rock plateau within the precincts of Wat Phuttho Thammatharo.

          Phu Mu Forest Park is a low hill with a large plateau in Amphoe Nikhom Kham Soi. Earlier, it used to be the home of wild boars but now is a location from where a splendid view of Mukdahan Province can be appreciated. Mukdahan National Park, a deciduous forest with unusual rock formations, is a must see. The most striking area of the park is Phu Pha Thoep, an area littered with peculiar shaped rocks. Phu Tham Phra is the largest mountain in this park and the site of a waterfall and cave full of small wooden Buddha images. 

          Kaeng Kabao is a popular spot for locals to sit by the Mekong River. A rock plateau is a favorite location for relaxation. During the dry season small islands and beaches emerge making this stretch of river a very beautiful spot, especially at sunset.

          Although there is no direct train from Bangkok to Mukdahan Province, tourists can take a Bangkok-Ubon Ratchathani train and then take a connecting bus to Mukdahan. Tourists can also fly from Bangkok to Ubon Ratchathani or Nakhon Phanom and then take a connecting bus to Mukdahan.